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Cocaine-induced Elk-1 hyperphosphorylation depends on ERK activation. Elk-1 hyperphosphorylation was analyzed using an anti-active antibody (anti phospho-Ser383-Elk-1) 10 min after cocaine injection in the absence or presence of SL 327. Note the strong induction of Elk-1 activation by cocaine in the dorsomedial striatum (DM) and in the shell of the NA. This activation is totally inhibited by SL 327 (data are representative of 4 independent mice for each group).
