Fig. 5.

Expression of ΔK11 Rb suppresses the death of cortical neurons evoked by camptothecin. Neuronal cultures were uninfected or infected for 24 hr with adenovirus expressing ΔK11 Rb or GFP before camptothecin treatment for 16 hr. Each point is the mean ± SEM of combined data from three independent experiments (each independent experiment performed in triplicate) and is expressed relative to the number of neurons present at the initial time of camptothecin treatment. * indicates significance (p < 0.02, Student's ttest) compared with GFP-infected cultures treated with camptothecin.