Skip to main content
. 2000 May 1;20(9):3104–3114. doi: 10.1523/JNEUROSCI.20-09-03104.2000

Fig. 9.

Fig. 9.

Expression of DN DP1 suppresses the death of cultured sympathetic neurons evoked by UV irradiation. Control viruses for each vector were generated by removal of the start codon from the insert. F denotes that the protein has a FLAG epitope attached to the C terminal. Effects of expression of (Δ1–126) DN DP1, a dominant-negative mutant containing an N-terminal truncation from amino acids 1–126 (A), and of (Δ103–126) DN DP1F, a FLAG-tagged dominant-negative mutant containing a DNA-binding domain deletion of amino acids 103–126, (Δ233–272) DP1F, a FLAG-tagged mutant containing the E2F-binding domain deletion of amino acids (233–272), and wild type (WT) DP1 (B) on the survival of sympathetic neurons after UV irradiation. A, Graph in which each point is the mean ± SEM of combined data from three independent experiments (each independent experiment performed in triplicate) and is expressed relative to the number of neurons present in each culture at the initial time of UV treatment. cont, Control.B, Representative experiment in which each point is the mean ± SEM of three cultures from the same experimental trial. Similar results were obtained in two independent experiments.