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. 2000 May 1;20(9):3221–3232. doi: 10.1523/JNEUROSCI.20-09-03221.2000

Fig. 6.

Fig. 6.

BDNF regulation of mEPSC amplitude does not require activity. A, The addition of 5 μmTTX to block action potential activity for the entire duration of the treatment period did not block the enhancement of mEPSC amplitude by BDNF; mEPSC amplitudes increased by 31 and 53% with and without TTX treatment, respectively. Means ± SEM are shown; without TTX,n = 38 and 30 for BDNF and TrkB-IgG groups, respectively, p < 0.01 by ANOVA; with TTX,n = 39 and 29 for BDNF and TrkB-IgG groups, respectively, p < 10−4 by ANOVA. B, BDNF, TTX, or BDNF and TTX treatment together did not significantly alter mEPSC frequency. Means ± SEM are shown; without TTX, n = 38 and 30 for BDNF and TrkB-IgG groups, respectively, p > 0.99 by ANOVA; with TTX, n = 39 and 29 for BDNF and TrkB-IgG groups, respectively, p > 0.93 by ANOVA.