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. 2000 May 1;20(9):3221–3232. doi: 10.1523/JNEUROSCI.20-09-03221.2000

Fig. 7.

Fig. 7.

BDNF increases GABAA receptor-mediated mIPSC frequency but not amplitude. A, Population averages of pharmacologically isolated GABAAreceptor-mediated mIPSCs from all cells in each treatment group show similar amplitude and time courses; n = 35, 31, and 33 for BDNF (top), control (middle), and TrkB-IgG (bottom) groups, respectively. Data were acquired continuously under voltage clamp at 2.5 kHz and filtered at 1 kHz. B, Representative recordings of GABAA receptor-mediated mIPSCs on a compressed time base show the elevation of mIPSC frequency induced by BDNF treatment;traces from neurons in BDNF (top), control (middle), and TrkB-IgG (bottom) groups are shown. C, In contrast, BDNF treatment had no effect on GABAA receptor-mediated mIPSC amplitude. Means ± SEM are shown; n = 35, 31, and 33 for BDNF, control, and TrkB-IgG groups, respectively. D, BDNF treatment increased mIPSC frequency by ∼1.8 fold compared with controls. *p < 0.028 indicates a significant difference by ANOVA between BDNF and either control or TrkB-IgG treatment groups; n = 35, 31, and 35 for BDNF, control, and TrkB-IgG groups, respectively.