Fig. 4.

A, Infarct volume was 29% smaller in Dnmt^S/+ mice compared withDnmt^+/+ mice after 30 min filamentous middle cerebral artery occlusion (MCAo) and 72 hr reperfusion. Brain lesion volume was determined on serial coronal hematoxylin and eosin-stained cryostat sections (20 μm).B, Dnmt^S/+ mice had significantly higher numbers of viable cells in ischemic striatum after 30 min MCAo/72 hr reperfusion compared with controls. Viable cells with neuronal appearance were counted on coronal sections (20 μm) through the anterior commissure. Mean ± SE. n = 14 and 15 animals per group. *p < 0.05 compared withDnmt^+/+ mice. Student'st test.