Table 3.
Chemical coding of submucosal neurons that respond to mucosal applications of 5-HT
| Neurons (total) | NPY | Dynorphin+/NPY− | CGRP | Calbindin | Calretinin | |
|---|---|---|---|---|---|---|
| Putative function | Cholinergic secretomotor3-a | VIP secretomotor3-b | Cholinergic secretomotor or ?3-d | Cholinergic primary afferent3-e | Cholinergic interneurons3-c | |
| Fast EPSP | 26 /39 | 4 /26 | 2 /20 | 0 /4 | 0 /26 | 2 /7 |
| Slow EPSP | 13 /39 | 0 /13 | 0 /13 | 2 /6 | 0 /10 |
The presumed chemical coding of submucosal neurons and their deduced functions have been reviewed in detail (Bornstein and Furness, 1992; Costa et al., 1992; Gershon et al., 1994).
F3-a
Putative coding: ChAT/CGRP/dynorphin/CCK/neuromedin U/NPY/somatostatin.
F3-b
Putative coding: VIP/dynorphin/galanin/neuromedin U.
F3-c
Putative coding: ChAT/calretinin.
F3-d
Putative coding: Possibly the ChAT/CGRP/dynorphin/CCK/neuromedin U/NPY/somatostatin group, but may also reside in a primary afferent/interneuron (see Discussion).
F3-e
Putative coding: ChAT/substance P/calbindin.