Table 2.
LD | Constant dark | |||||||
---|---|---|---|---|---|---|---|---|
Vehicle | Modafinil (150 mg/kg) | Mann–Whitney pvalue | Vehicle | Modafinil (75 mg/kg) | Modafinil (150 mg/kg) | Modafinil (300 mg/kg) | Kruskal–Wallis pvalue | |
n | 6 | 7 | 7 | 6 | 6 | 4 | ||
VLPO | 52 ± 7 | 26 ± 3* | 0.007 | 44 ± 5 | 20 ± 5* | 24 ± 4* | 21 ± 3* | 0.007 |
SCN | 56 ± 19 | 89 ± 23 | NS | 11 ± 3 | 17 ± 11 | 28 ± 7 | 6 ± 2 | NS |
AHA | 84 ± 15 | 103 ± 6 | NS | 75 ± 10 | 51 ± 5 | 72 ± 15 | 67 ± 8 | NS |
PFx | 45 ± 9 | 72 ± 10 | NS | 33 ± 7 | 39 ± 7 | 52 ± 9 | 58 ± 14 | NS |
TMN | 8 ± 4 | 43 ± 5* | 0.003 | 3 ± 1 | 20 ± 8 | 18 ± 7 | 22 ± 5 | 0.04 |
BSTLD | 20 ± 4 | 74 ± 9* | 0.003 | 19 ± 3 | 45 ± 5* | 62 ± 9* | 65 ± 9* | 0.008 |
CeL | 42 ± 13 | 133 ± 12* | 0.008 | 28 ± 6 | 74 ± 15 | 149 ± 25* | 142 ± 18* | 0.007 |
Striatum | 1 ± 0 | 116 ± 19* | 0.003 | 1 ± 0 | 22 ± 13 | 94 ± 24* | 102 ± 21* | 0.002 |
Statistically different from vehicle by the use of apost hoc Scheffe test.