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. 2000 Nov 15;20(22):8572–8576. doi: 10.1523/JNEUROSCI.20-22-08572.2000

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Fig. 1. — LTD in the CA1 region in vivo is dependent on protein translation. A, A low-frequency train (LFS) in the presence of a vehicle injection (n = 6) results in a robust LTD that persists for >8 hr. Injection of the protein translation inhibitors anisomycin (240 μg/5 μl; n = 10) or emetine (240 μg/5 μl;n = 7) 2 hr before LFS completely inhibits the expression of LTD from ∼4.5 hr after LFS. B,Anisomycin (240 μg/5 μl; n = 6) or emetine (240 μg/5 μl; n = 7) have no effect on basal synaptic transmission compared to vehicle-injected controls (n = 6). C, Original analog traces showing evoked responses in the CA1 region at three time points: preinjection, t = 5 min and t = 8 hr after LFS, in (i) a vehicle-injected animal and (ii) an animal injected with anisomycin (240 μg/5 μl). Calibration: 5 msec, 5 mV. Line breaks indicate change in time scale.