Fig. 2.

Postsynaptic action potentials or EPSPs alone are not sufficient to induce LTD. A, The mean EPSP amplitude is plotted against time. Three hundred sixty action potentials were evoked in the postsynaptic cell at a frequency of 1 Hz from a membrane potential of −70 mV. This protocol did not change the EPSP amplitude (n = 3). B, Three hundred sixty EPSPs at a membrane potential of −70 mV, as shown in theinset, evoked at a frequency of 1 Hz did not change the EPSP amplitude (n = 3). The induction paradigms were applied at the times indicated by the arrows. Insets represent the first three sweeps of the induction paradigm of a representative experiment.