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. 2000 Nov 15;20(22):8290–8297. doi: 10.1523/JNEUROSCI.20-22-08290.2000

Fig. 3.

Fig. 3.

Associative LTD is dependent on activation of metabotropic glutamate receptors. A, The mean EPSP amplitude is plotted against time. In the presence of 500 μm MCPG, an antagonist of metabotropic glutamate receptors, the associative LTD was inhibited (n = 6). B, The NMDAR antagonist d-AP-5 (50 μm) was without effect on both basal synaptic transmission and the induction of associative LTD (n = 6). C, Nine hundred EPSPs at a membrane potential of −62 mV (inset), evoked at a frequency of 1 Hz (indicated by the arrow) reliably depressed the EPSP amplitude (n = 8).D, LFS-induced LTD was blocked by the application of 50 μmd-AP-5 (n = 4).Insets in A and Crepresent the first three sweeps of the induction paradigm of a representative experiment. Horizontal bars indicate the presence of the MCPG and d-AP-5, respectively.