Table 2.

Targeted and untargeted treatment effects on grass and birch AIT groups on the total nasal symptom score (full analysis set)

	Treatment effect (ACC post‐treatment – ACC pretreatment), adjusted AUC of TNSS
	Grass AIT (N = 46)		Birch AIT (N = 48)
	Targeted treatment postgrass –pregrass	Untargeted treatment postbirch – prebirch	Targeted treatment postbirch – prebirch	Untargeted treatment postgrass – pregrass
n (missing)	40 (6)	41 (5)	43 (5)	42 (6)
Mean (SD)	−13.55 (12.55)	−3.32 (11.42)	−9.81 (14.01)	−6.29 (14.46)
95% CI (Mean)	−17.56, −9.54	−6.92, 0.29	−14.13, −5.50	−10.79, −1.78
Median	−12.5	−5.0	−7.0	−6.0
Min, Max	−38.0, 18.0	−25.0, 22.0	−70.0, 13.0	−43.0, 31.0
Q25, Q75	−23.0, −7.0	−10.0, 3.0	−17.0, −1.0	−15.0, 4.0
Within‐group comparison Targeted vs Untargeted
P‐value*	< 0.001		0.24
Between‐group comparison Targeted vs Untargeted for ACC grass : [postgrass – pregrass] on grass treatment vs [postgrass – pregrass] on birch treatment
P‐value*	0.02
Between‐group comparison Targeted vs Untargeted for ACC birch : [postbirch – prebirch] on birch treatment vs [postbirch – prebirch] on grass treatment
P‐value*	0.02

Abbreviations: ACC, allergen challenge chamber; AIT, allergen immunotherapy; AUC, area under the curve; CI, confidence interval; Max, maximum; Min, minimum; N, number of patients; n, number of patients with data; Q, quartile; SD, standard deviation; TNSS, total nasal symptom score.

*P‐value from 2‐sided 1‐sample t test.