Table 4. KEGG pathway enrichment results of upregulated DEGs in INF_24h comparing to NC.
| ID | Description | Gene ratio | P-value | Gene name | Count |
|---|---|---|---|---|---|
| ssc04060 | Cytokine-cytokine receptor interaction | 27/434 | 3.46E-04 | IFNB1, CXCL10, IFN-ALPHAOMEGA, TNFRSF12A, CXCL11, CCL5, TNFSF13B, TNFRSF1B, CCL2, IL15, CCR7, FLT4, IL22RA1, IL12A, IFNA1, KITLG, IL10RA, IL10, IL12RB1, AMHR2, CXCL12, TNFRSF9, IL11, HGF, MPL, AMH, TNFRSF11A | 27 |
| ssc04621 | NOD-like receptor signaling pathway | 21/434 | 1.01E-03 | GBP1, OAS1, IFNB1, STAT1, STAT2, IFN-ALPHAOMEGA, LOC100155195, TXNIP, CASP1, NAMPT, LOC100156073, IRF7, CCL5, LOC100523492, CCL2, TNFAIP3, IFNA1, TRAF6, BIRC3, ERBIN, XIAP | 21 |
| ssc04064 | NF-kappa B signaling pathway | 13/434 | 1.76E-03 | DDX58, TRIM25, PTGS2, TNFSF13B, VCAM1, CARD11, TNFAIP3, CFLAR, TRAF6, BIRC3, CXCL12, XIAP, TNFRSF11A | 13 |
| ssc04622 | RIG-I-like receptor signaling pathway | 11/434 | 4.75E-03 | IFNB1, DDX58, CXCL10, IFN-ALPHAOMEGA, TRIM25, CASP10, IRF7, CYLD, IL12A, IFNA1, TRAF6 | 11 |
| ssc04630 | Jak-STAT signaling pathway | 19/434 | 6.74E-03 | IFNB1, STAT1, STAT2, IFN-ALPHAOMEGA, SOCS1, FHL1, IL29, PIM1, IL15, IL22RA1, IL12A, IFNA1, CISH, IL10RA, IL10, IL12RB1, STAT4, IL11, MPL | 19 |
| ssc04623 | Cytosolic DNA-sensing pathway | 8/434 | 2.43E-02 | IFNB1, DDX58, CXCL10, IFN-ALPHAOMEGA, CASP1, IRF7, CCL5, IFNA1 | 8 |
Innate immune response-related pathways were represented in this table.