Up-regulation of IDO1 increases levels of inflammatory factors in macrophages (pg/mL). * p< 0.05 vs. the vehicle group. Statistical values were measurement data and analyzed using one-way ANOVA. n = 3. The experiment was repeated 3 times independently. IDO1, indoleamine 2,3-dioxygenase-1; NC, negative control; oe, overexpression; 1-MT was the inhibitor of IDO1; IL, interleukin; TNF-α, tumor necrosis factor-α; ANOVA, analysis of variance.