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. Author manuscript; available in PMC: 2020 Sep 10.
Published in final edited form as: Vaccine. 2019 Aug 12;37(38):5708–5716. doi: 10.1016/j.vaccine.2019.07.103

Figure 5: Prime-boost vaccination provides long term protection against pneumonic infection.

Figure 5:

Male C57BL/6 mice were primed with rF1-V + Alhydrogel alone (AL) or rF1-V + Alhydrogel + SA-4-1BBL (AL+BBL). 21 d later, mice were boosted with rF1-V + Alhydrogel (ALH; n=5), rF1-V + SA-4-1BBL (BBL; n=5), or rF1-V + Alhydrogel + SA-4-1-BBL (AL+BBL; n=5). Mice were challenged 150 d after prime vaccination with 10 LD50 of virulent Y. pestis CO92 LuxPcysZK and monitored for survival for 14 d. Data was analyzed using Kaplan-Meier survival curve and log-rank test.