Table 3.

CTC analysis of matched CSF and blood.

Patient PT1	Baseline	C2D1*	C3D1*	CNS Progression/off study
ctc csf	328	76	117
CTC Blood	0	Not done	0
CSF cytology	Positive	Negative	Positive
MRI brain/spine	lesions present	Not done	Stable
CTCAP	No lesions	Not done	No lesions
Patient PT14	Baseline	C2D1	C3D1	C5D1	C7D1	CNC Progression/off study
CTC CSF	22	13	13	2	9
CTC Blood	14	0	0	0	1
CSF cytology	Atypical/Positive**	Negative	Atypical/Negative**	Negative	Atypical/Negative**
MRI brain/spine	No lesions	Not done	Stable	Stable	Stable
CT CAP	lesions present	Not done	Stable	Stable	Stable
Patient PT10***	Baseline	C2D1	C3D1	CNS Progression/off study
CTC CSF	2	3	1
CTC Blood	0	1	0
CSF cytology	Suspicious/Negative**	Negative	Negative
MRI brain/spine	Lesions present	Not done	Stable
CT CAP	Lesions present	Not done	Stable

Abbreviations: CTC, circulating tumor cell, CSF, cerebrospinal fluid, MRI, magnetic resonance imaging, CT CAP, computer tomography

of chest/abdomen/pelvis.

^*Study specified assessments made prior to the start of cycle 2,3,5, and 7. Patients were taken off study for progression of disease

based on non-study scheduled clinical, cytologic, or radiologic assessments made during clinical follow up.

^**if the CSF cytology was atypical or suspicious, a repeat CSF study was conducted for a confirmatory testing.

^***PT10 had concurrent brain and spinal cord metastases.