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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Antiviral Res. 2019 Aug 1;170:104573. doi: 10.1016/j.antiviral.2019.104573

Fig 1. Comparing infection with diverse CCHFV strains in IFNAR−/− mice.

Fig 1.

(A) Phylogenetic designation by clade of CCHFV (listed by GenBank no. and strain name) based on full-length S-genome segment (for full details of tree construction see supplementary methods). Strains used for in vivo comparison in mice are indicated by black arrowheads. (B) Weight change and (C) survival in mice inoculated SC with a target dose of 1 × 102 TCID50 of indicated CCHFV strains. (D) RT-PCR analyses of viral RNA (S segment) in blood and tissues, and (E) antibody activity units (AAU) of anti-NP IgM or IgG, and anti-Gc IgG in plasma collected when mice reached end-point criteria (open symbols) or at completion of the study (closed symbols; 21 dpi). Time post-infection of sampling, outcome, and corresponding antibody levels for individual mice is provided in Supplementary Table 1.