Figure 1.

Vaccination with KEX1 induces a robust immune response. (a) Schematic representation of the vaccination strategy and treatment administration. (b) Mean reciprocal endpoint titer of anti-KEX1 IgG antibodies as determined by ELISA. Dotted lines on the X-axes indicate the times of vaccination. The period for administration of the immunosuppressive regimen is highlighted in grey. Dashed line indicates correlate of protection of 10⁴ RET. (c) Ratio of KEX1 Antibody-secreting cells from total IgG-secreting cells, as determined by ELISpot. Mann–Whitney test was performed to evaluate the differences between the sham and vaccinated groups. *p < .05, **p < .01, ***p < .001.