Table 2.
Estimated mediating effects of select CpG sites in the association of 30 pack-years of smoking among current smokers with bladder cancer risk in the Women’s Health Initiative.
| Component of ERR estimatea |
Percent of ERR estimatea |
||||
|---|---|---|---|---|---|
| CpG site | Component of smoking ERR | Estimate | 95% CI | Estimate | P-value |
| cg05575921 | CDE | 0.18 | (−1.94, 2.29) | 5% | 0.86 |
| INTref | 0.09 | (0, 0.17) | 3% | 0.05 | |
| INTmed | 2.29 | (0.02, 4.55) | 72% | 0.02 | |
| PIE | 0.64 | (−0.38, 1.66) | 20% | 0.21 | |
| TE | 3.19 | (0.43, 5.95) | 100% | - | |
| cg03636183 | CDE | 2.06 | (−1.47, 5.58) | 77% | 0.09 |
| INTref | 0.03 | (−0.15, 0.21) | 1% | 0.74 | |
| INTmed | 0.90 | (−1.16, 2.95) | 34% | 0.45 | |
| PIE | −0.32 | (−0.60, −0.03) | −12% | 0.15 | |
| TE | 2.67 | (0.21, 5.13) | 100% | - | |
| cg19859270 | CDE | 0.46 | (−1.66, 2.58) | 17% | 0.64 |
| INTref | 0.10 | (−0.03, 0.23) | 4% | 0.13 | |
| INTmed | 1.89 | (0.04, 3.75) | 72% | 0.04 | |
| PIE | 0.18 | (−0.38, 0.74) | 7% | 0.52 | |
| TE | 2.63 | (0.24, 5.03) | 100% | - | |
aMediation models were adjusted for race/ethnicity, education, WHI arm, age at baseline, year of enrollment, follow-up time, and DNA extraction method.
Abbreviations: ERR = excess relative risk; CDE = controlled direct effect; INTref = reference interaction; INTmed = mediated interaction; PIE = pure indirect effect; TE = total effect