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. 2019 Apr 15;15(9):2090–2105. doi: 10.1080/21645515.2019.1581536

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© 2019 GlaxoSmithKline Biologicals SA. Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Specificity of T-cell responses in DENV-unprimed subjects. The magnitudes and specificity of background (medium)-subtracted T-cell responses to different DENV antigens measured at 1 month after the second dose (Month 7) by IFN-γ ELISPOT are presented. Samples were collected from a subset of US subjects (with subject numbers indicated) who were DENV-unprimed at baseline. Each bar represents the response of one subject. A response was considered positive if it was ≥55 spot-forming units (SFU) per 10⁶ PBMC, and exceeded response to the negative control by four-fold. (a) Magnitudes of T-cell responses to individual DENV-2 antigens measured after stimulation with peptide pools covering DENV-2 nonstructural (NS) 1, NS2, NS3, NS4, NS5, capsid (C), premembrane (PrM) and envelope (E) proteins are presented. (b) Relative proportions of the T-cell response to DENV-1, DENV-2, DENV-3 and DENV-4 NS3 peptide pools were determined for the subjects with DENV-2 NS3 specific response in the analysis shown in (a).