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. 2019 Apr 15;15(9):2090–2105. doi: 10.1080/21645515.2019.1581536

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© 2019 GlaxoSmithKline Biologicals SA. Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — DENV-specific B-cell responses to tetravalent live-attenuated DENV vaccines in different study populations. (a) Frequencies of DENV-specific B-cells for the overall sample subsets of study populations in the US and Thailand (adults) and Puerto Rico (adults and adolescents) after immunization with F17 or F19 vaccine are presented. Blood samples were obtained prior to each dose (Day [D] 0 and month [M] 6), at 1 and 3 months after both the first dose (M1 and M3) and the second dose (M7 and M9). Box-and-whiskers plots represent the percentages of responding B cells with medians, first and third quartiles, and the minimum/maximum values measured. (b) B-cell responses in the Puerto Rican subjects after subtraction of the pre-vaccination responses by subject are presented. (c) B-cell responses in the US subjects stratified by their DENV priming status at baseline are presented, with numbers of evaluated subjects indicated (numbers may vary by time-point and serotype).