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. 2019 Jun 26;14(11):1125–1140. doi: 10.1080/15592294.2019.1633867

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 5. — EZH2 and c-MYC mediated IGF1R regulation. (a) Fold change of mRNA expression levels regarding EZH2, c-MYC and IGF1R in EZH2, c-MYC and double-transfected siRNA downregulated HG3 cells. (b) Western blot analysis showing protein levels for different antibodies in EZH2, c-MYC and double-transfected siRNA downregulated HG3 cells. (c and d) ChIP assay data showing fold enrichment of EZH2 and c-MYC antibody over IgG Ab on IGF1R promoter in EZH2 and c-MYC siRNA downregulated HG3 cells. (e and f) Fold change expression of EZH2, c-MYC and IGF1R in DZNep and JQ-1 treated HG3 cells. (g) Expression levels of EZH2 and IGF1R for IGF1R transfected HG3 samples. (h) Western blot analysis showing protein levels for different antibodies in IGF1R siRNA downregulated HG3 cells.