Table 3. Gene overlap between our three categories (D, D × S, D+D × S) and results from three previously published papers.
The first study (A+B) examines female transcriptomic response to dietary restriction and rapamycin across six different tissues (Dobson et al., 2018). The second study (C) characterises genes that respond to TORC1 inhibition via the transcription factors REPTOR and REPTOR-BP (Tiebe et al., 2015). In italics we show the total number of genes in that category, with bold counts showing the significant (p<0.05) overlaps between two categories. Overlap is assessed with Fisher's exact tests, p-values are provided below the counts.
| A. Dietary Restriction | ||||
|---|---|---|---|---|
| Brain (167) |
Thorax (193) |
Gut (25) |
Fatbody (358) |
|
| D (639) |
27
p<0.001 |
51
p<0.001 |
14
p<0.001 |
58
p<0.001 |
| D × S (51) |
5
p=0.0026 |
5
p=0.0048 |
0 p=1 |
7
p=0.0041 |
| D+D × S (116) |
10
p<0.001 |
19
p<0.001 |
3
p=0.004 |
20
p<0.001 |
| B. Rapamycin | ||||
| Brain (58) |
Thorax (38) |
Gut (76) |
Fatbody (222) |
|
| D (639) |
14
p<0.001 |
9
p=0.0012 |
17
p<0.001 |
57
p<0.001 |
| D × S (51) |
5
p<0.001 |
2
p=0.02 |
2 p=0.07 |
3 p=0.13 |
| D+D × S (116) |
6
p<0.001 |
7
p<0.001 |
4
p=0.017 |
16
p<0.001 |
| C. TORC1 | ||||
| REPTOR/REPTOR-BP (212) |
||||
| D (639) |
28
p=0.019 |
|||
| D × S (51) |
1 p=0.78 |
|||
| D+D × S (116) |
9
p=0.0068 |
|||