Table 1.
Age, Body Composition, and Endocrine and Metabolic Parameters of Subjects
| Control Subjects | PCOS | |||
|---|---|---|---|---|
| Lean | Obese | Lean | Obese | |
| Age, y | 30 ± 2 | 30 ± 2 | 28 ± 1 | 29 ± 2 |
| Height, cm | 165.3 ± 1.6 | 163.9 ± 2.6 | 163.3 ± 1.9 | 161.7 ± 3.3 |
| Body weight, kg | 61.0 ± 2.0 | 94.0 ± 4.0a,b | 61.1 ± 1.7 | 89.2 ± 3.9c,d |
| BMI, kg/m2 | 23.0 ± 0.8 | 34.9 ± 0.7a,b | 22.9 ± 0.4 | 34.0 ± 0.8c,d |
| Total body fat, % | 29.5 ± 1.8 | 42.3 ± 0.9a,b | 32.1 ± 1.9 | 43.8 ± 1.2c,d |
| Truncal fat, % | 24.7 ± 2.4 | 41.9 ± 1.4a,b | 28.1 ± 2.3 | 43.2 ± 1.4c,d |
| Central fat (R1), g | 759 ± 87 | 2137 ± 135a,b | 913 ± 93 | 2117 ± 114c,d |
| Systolic blood pressure, mm Hg | 114 ± 4 | 127 ± 3 | 116 ± 5 | 122 ± 4 |
| Diastolic blood pressure, mm Hg | 72 ± 2 | 76 ± 3 | 70 ± 4 | 76 ± 2 |
| TBARS, nmol/mL | 2.3 ± 0.3 | 2.5 ± 0.3 | 2.5 ± 0.2 | 2.8 ± 0.2 |
| Fasting glucose, mg/dL | 89 ± 2 | 89 ± 2 | 86 ± 3 | 92 ± 2 |
| 2-Hour glucose, mg/dL | 97 ± 5 | 86 ± 9 | 95 ± 8 | 134 ± 8c,d,f |
| Fasting insulin, µU/mL | 4.1 ± 1.1 | 15.5 ± 3.0a,b | 7.6 ± 1.3 | 19.3 ± 4.1c,d |
| ISOGTT | 14.1 ± 2.2 | 5.4 ± 1.0a | 7.7 ± 1.1e | 3.0 ± 0.4c,d |
| Total cholesterol, mg/dL | 143 ± 6 | 141 ± 6b | 173 ± 6e | 183 ± 9c,f |
| Triglycerides, mg/dL | 58 ± 6 | 81 ± 11 | 62 ± 5 | 143 ± 22c,d,f |
| HDL cholesterol, mg/dL | 53 ± 3 | 48 ± 3 | 55 ± 2 | 49 ± 4c,d |
| LDL cholesterol, mg/dL | 78 ± 7 | 76 ± 6b | 106 ± 5e | 107 ± 7c,f |
| LH, mIU/mL | 6.6 ± 0.5 | 4.7 ± 0.8b | 14.4 ± 1.7e | 13.4 ± 1.8c,f |
| Testosterone, ng/dL | 32.3 ± 5.2 | 25.5 ± 4.3b | 62.8 ± 4.5e | 72.3 ± 6.8c,f |
| Androstenedione, ng/mL | 1.7 ± 0.2 | 2.1 ± 0.2b | 4.0 ± 0.3e | 3.9 ± 0.2c,f |
| DHEA-S, µg/dL | 211 ± 22 | 157 ± 22 | 256 ± 34 | 205 ± 27 |
| Testosterone, AUC | 3401 ± 453 | 3700 ± 201b | 6468 ± 786e | 7130 ± 1137c,f |
| Androstenedione, AUC | 576 ± 51 | 329 ± 37b | 506 ± 31e | 576 ± 51c,f |
| 17OH-progesterone, AUC | 10,112 ± 1226 | 9848 ± 594b | 21,387 ± 2859e | 23,057 ± 2782c,f |
Values are expressed as means ± SE. Conversion factors to SI units: testosterone, ×3.467 (nmol/L); androstenedione, ×3.492 (nmol/L); DHEA-S, ×0.002714 (µmol/L); glucose, ×0.0551 (mmol/L); insulin, ×7.175 (pmol/L).
Abbreviation: HDL, high-density lipoprotein.
a
Obese control vs lean control, P < 0.006.
b
Obese control vs lean PCOS, P < 0.05.
c
Obese PCOS vs lean control, P < 0.002.
d
Obese PCOS vs lean PCOS, P < 0.02.
e
Lean PCOS vs lean control, P < 0.007.
f
Obese control vs obese PCOS, P < 0.001.