Table 2:
Differences in coagulation measurements between subjects with BMI ≥ 30 kg/m2 and BMI < 30 kg/m2 following injury. Data presented as median (25–75 interquartile range) or sample size (%) as appropriate.
| BMI< 30 kg/m2 | BMI ≥ 30 kg/m2 | P value * | |
|---|---|---|---|
| INR | 1.12 (1.03 – 1.25) | 1.08 (1.01 – 1.21) | 0.08 |
| INR>1.3 (%) | 99 (19) | 25 (16) | 0.91 |
| PTT | 27.2 (24.4 – 31.0) | 26.3 (24.0 – 30.0) | 0.13 |
| PTT > 35 | 76 (15) | 24 (15) | 0.92 |
| ACT (seconds) | 121 (113 – 128) | 121 (113 – 128) | 0.60 |
| ACT <128 seconds | 197 (39) | 51 (34) | 0.22 |
| MA (mm) | 62.5 (56.8 – 66.3) | 66.0 (61.0 – 69.4) | <0.01 |
| MA<55 mm (%) | 92 (18) | 9 (6) | <0.01 |
| Angle (degrees) | 72.2 (66.7 – 75.7) | 74.3 (67.8 – 77.7) | <0.01 |
| Angle<65 degrees (%) | 94 (19) | 15 (10) | 0.01 |
| LY30 (%) | 1.8 (0.9 – 3.0) | 1.7 (0.5 – 2.9) | 0.17 |
| Fibrinolysis shutdown (LY30<0.6%) (%) | 63 (14) | 31 (23) | 0.01 |
| Physiologic fibrinolysis | 344 (77) | 99 (74) | 0.44 |
| (LY30 0.6–7.6%) (%) | |||
| Hyperfibrinolysis (LY30>7.7%) (%) | 39 (9) | 4 (3) | 0.03 |
| Functional fibrinogen (mg/dL) | 410(347–475) | 452 (383 – 502) | <0.01 |
| Functional fibrinogen <356mg/dL (%) | 141 (29) | 27 (18) | <0.01 |
BMI- Body Mass Index - INR – International Normalized Ratio, PTT – Partial Thromboplastin Time, ACT – Activated clotting time, MA – Maximal Amplitude, LY30 – lysis 30 minutes after MA