Table 3.
The contribution of CYPs and non-CYP enzymes in the minor metabolism of drugs
| Metabolizing enzymes | The number of drugs | |
|---|---|---|
| Overview | Established* | Newly-approved* |
| CYP | 28 | 78 |
| Non-CYP | 6 | 27 |
| Unknown | 124 | 144 |
| CYP metabolism | ||
| CYP1A2 | 5 | 11 |
| CYP2B6 | 2 | 4 |
| CYP2C8 | 2 | 15 |
| CYP2C9 | 3 | 20 |
| CYP2C19 | 3 | 26 |
| CYP2D6 | 8 | 23 |
| CYP3A4 | 14 | 19 |
| CYP3A5 | 2 | 3 |
| Non-specified CYPs | - | 3 |
| Other CYPs | 3 | 11 |
| Non-CYP metabolism | ||
| ADH ALDH | - | 1 |
| CESs | 1 | 1 |
| FMO MAO | - | 6 |
| Unknown | - | 1 |
| SULTs | 1 | 2 |
| UGTs | 4 | 16 |
*
Top 200 most prescribed drugs (established) and newly FDA approved drugs from 2005 to 2016 (newly-approved)
Drugs, that are weighed once under P450 metabolism can be metabolized by multiple CYP isoforms like CYP3A4, CYP2C9 and CYP2C19. Hence the P450 subtypes will not add up in most cases to overall P450 and non-P450 mediated metabolism.