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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Sex Med Rev. 2019 Jul 17;7(4):604–613. doi: 10.1016/j.sxmr.2019.05.005

Figure 2.

Figure 2.

Toll-like receptor signaling – general features of the canonical pathway. The myeloid differentiation primary response 88 (MyD88) is an innate immune signal transduction adaptor common for almost all TLR (except for the TLR3), which recruits interleukin 1 receptor-associated kinase (IRAK). The IRAK interacts with adapter protein tumor necrosis factor-associated factor 6 (TRAF6), leading to nuclear factor kappa light chain enhancer of activated B cells (NF-kB) translocation to the cellular nuclei. The TLRMyD88 signaling pathway results in increased pro-inflammatory cytokines and interferon production.