Figure 3.

Replication of the relationship between cognition and white matter vulnerability to schizophrenia that were reported in Kochunov et al 2017 (for convenience to the readers, the figure of original findings in the U.S. sample is reproduced in Supplementary Figure 1). X-axis: Effect sizes of the 21 major white matter regions in ENIGMA, higher values indicate more severe impairment in schizophrenia compared with controls in the ENIGMA meta-analysis. Y-axis: The correlation coefficients between FA of each region and cognitive measures in processing speed (PS) or working memory (WM) in the current Chinese sample. Full sample: all participants combined. Patients: all patients combined. A: Relationship between correlation coefficients for regional FA - processing speed (PS) (y-axis) and regional FA effect sizes of schizophrenia from ENIGMA-Schizophrenia (x-axis, Cohen’s d). B: partial correlation coefficients of A after corrected for working memory (WM). C: Relationship between correlation coefficients for regional FA values and working memory (y-axis) and regional FA effect sizes of schizophrenia (x-axis). D: partial correlation coefficients of C after corrected for PS. This was tested in the full sample (A to D) and then patients (E to H) and controls (I to L) separately.