Table 2.

MCCB cognitive domain and total scores, and associations with treatment stages and RVI. All analyses included age and sex as covariates.

	A: MCCB Associations with Treatment Status												B: MCCB Associations with RVI in Patients
	Testing schizophrenia-related cognitive deficits						Testing treatment-resistance related cognitive deficits
	Treatment Initiation (N=45)		Controls (N=78)		Analysis		Treatment Resistant (N=37)		Treatment Responsive (N=40)		Analysis		Treatment Initiation (N=45)		Treatment Responsive (N=40)		Treatment Resistant (N=37)
	Mean	SD	Mean	SD	t	p	Mean	SD	Mean	SD	t	p	r	p	r	p	r	p
Visual Learning	47.8	8.6	54.9	7.4	4.7	1·10−5**	42.4	11.8	46.0	11.5	1.4	0.2	0.0	0.9	−0.44	5·10−3*	−0.10	0.5
Verbal Learning	50.5	10.2	54.5	8.7	2.3	0.02	46.9	10.0	48.8	11.3	0.8	0.4	0.0	0.9	−0.39	7·10−3*	−0.12	0.4
Social Cognition	48.4	9.3	53.1	10.0	2.4	0.02	42.1	12.4	46.3	10.5	1.6	0.1	0.0	0.9	−0.08	0.6	0.0	0.9
Reasoning and Problem Solving	43.9	7.8	57.9	7.4	9.1,	2·10−15**	45.3	9.8	45.7	9.8	0.2	0.9	−0.15	0.3	−0.11	0.5	−0.10	0.5
Processing Speed	47.3	7.3	57.2	7.9	6.3	6·10−9**	43.8	11.9	45.3	9.9	1.0	0.3	−0.10	0.4	−0.53	7·10−4**	−0.16	0.3
Working Memory	47.0	9.8	47.0	6.9	7.1	1·10−10**	39.3	14.1	46.8	10.7	2.9	0.004*	−0.05	0.6	−0.24	0.12	−0.12	0.4
Total Score	46.8	7.9	58.9	6.8	8.2	1·10−12**	40.0	11.1	45.2	11.5	2.5	0.1	0.0	0.9	−0.42	5·10−3*	−0.10	0.5

^*Nominally significant (p<0.05)

^**Statistically significant after Bonferroni correction for 14 comparisons (p<0.05/14=0.0036) for Table 2A, and 21 correlation analyses (p<0.05/21=0.0024) for Table 2B