Table 2.
Gene networks enriched amongst genes differentially expressed in granulosa cells from cows with metritis.
| Gene network1 | Network score2 | Genes differentially expressed3 | |
|---|---|---|---|
| Upregulated | Downregulated | ||
| Developmental Disorder, Neurological Disease, Cardiovascular Disease | 36 | ALDOB, ARHGEF2, BAZ2A, CAP1, HGFAC, KCNQ3, MYL3, PKN3, SERPINA12, SLC2A4, SOX5, SSH1, THBS4, TRIB3, TRIM40, VSNL1 | DTNA, NR4A1, PIDD1, SIK1 |
| Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking | 34 | CALB1, CDKN2B, CLEC4G, GZMA, HLAB, IL18, KLRC1, KLRD1, KLRK1, MST1, NCR1, PLA2G2A, RASGRP3, RGS5, SELENOS, SYNE2, ZNF292 | ID4, NR4A2 |
| Cell Signaling, Molecular Transport, Nucleic Acid Metabolism | 32 | ADCYAP1, CHGA, GABBR1, GCG, MAPKAP1, MRPS6, NCF2, NDNF, NPY2R, PPY, SST | CHAC1, CRYM, KLHL24, LHCGR, MN1, NR5A2, TTR |
| Cell Cycle, Cellular Assembly and Organization, DNA Replication, Recombination, and Repair | 25 | A4GNT, ARPP19, CCDC63, CLRN3, FAM131A, FAM207A, FANCE, GPR25, HOXC11, PAN3, RAB5C, SLC27A6, TKTL2, VGLL4, | HELQ |
| Cancer, Cellular Development, Organismal Injury and Abnormalities | 23 | C20orf196, CHP2, CRCT1, EIF5A2, FGF14, PCTP, POC5, PRICKLE1, SIX4, SMG8, SPATC1L | ACADM, ACSM1, STX17 |
| Cellular Function and Maintenance, Cellular Growth and Proliferation, Amino Acid Metabolism | 21 | ANKRD17, ATOH1, BTN1A1, CD28, CDX1, CNIH4, F3, FGFR3, HSD17B2, MAT1A, PCDH7, VCL | PDLIM3 |
1
Enriched gene networks determined by Ingenuity Pathway Analysis using significantly differentially expressed genes only.
2
Network score is derived from a P-value and indicates the likelihood of the genes in a network being found together due to random chance. A network score of 2 or greater gives a 99% confidence the network and genes not being generated by random chance alone.
3
Genes are differentially regulated in metritis cows.