Table 3.
Predicted upstream regulators of differentially expressed genes.
| Upstream regulator | Predicted activation state | Z-score | Differentially expressed target molecules |
|---|---|---|---|
| NFκB (complex) | Activated | 2.908 | CALB1, CDX1, F3, HGFAC, IL18, LHCGR, NCF2, PLA2G2A, SLC2A4, SOX5, TRIB3, VSNL1 |
| TCF7L2 | Activated | 2.414 | CAP1, GCG, ID4, PRICKLE1, TRIM59, UGT8 |
| IL21 | Activated | 2.407 | CD28, GZMA, KLRC1, KLRD1, KLRK1, NCR1 |
| E. coli B5 lipopolysaccharide | Activated | 2.219 | F3, IL18, MAT1A, NCF2, TTR |
| ITK | Activated | 2.219 | KLRC1, KLRD1, KLRK1, NCR1, PRKCB |
| NEUROG3 | Activated | 2.2 | CHGA, EN1, GCG, PPY, SST |
| IL12 (complex) | Activated | 2.176 | CD28, GZMA, IL18, KLRC1, KLRD1, NCR1 |
| RAS | Activated | 2 | ARHGEF2, CDKN2B, CDX1, GCG |
| FGF1 | Inhibited | −2.236 | EN1, NDNF, NR4A2, PRICKLE1, TTR |
| methylprednisolone | Inhibited | −2.216 | ALDOB, AQP8, C9, F3, HSD17B2, PCTP |
| cycloheximide | Inhibited | −2.213 | ADCYAP1, GCG, NR4A1, PLA2G2A, SST |
| HES1 | Inhibited | −2 | ATOH1, CHGA, GCG, SST |