Table I. VE-PTP inhibitor experiment; significantly enriched proteins upon AKB-9778 inhibition and 4G10 immunoaffinity enrichment (p < 0.05).

Protein names	Gene names	Peptides	Score	MS/MS count	−log10 p value	log2 difference	fold difference
SH2 domain-containing adapter protein B	Shb	8	17.04	19	2.37	4.69	25.74
Bone morphogenetic protein receptor type-2	Bmpr2	9	15.19	21	2.46	4.50	22.65
Ephrin type-B receptor 4	Ephb4	37	257.22	249	1.79	4.20	18.41
Vacuolar protein sorting-associated protein 37C	Vps37c	6	50.15	30	2.16	3.80	13.97
Cytohesin-1	Cyth1	12	22.98	51	1.74	3.72	13.15
FYVE, RhoGEF and PH domain-containing protein 5	Fgd5	28	136.07	157	2.05	3.52	11.46
SH3 and multiple ankyrin repeat domains protein 3	Shank3	47	323.31	565	1.80	3.35	10.16
Tensin-like C1 domain-containing phosphatase	Tenc1	33	68.97	147	2.84	3.31	9.92
Roundabout homolog 2	Robo2	4	9.83	12	1.78	3.25	9.52
Angiopoietin-1 receptor	Tie2/Tek	50	323.31	901	3.73	3.22	9.35
Beta-chimaerin	Chn2	5	9.66	15	1.56	3.18	9.05
Probable E3 ubiquitin-protein ligase MID2	Mid2	9	43.57	24	1.37	3.12	8.71
Tyrosine-protein kinase receptor Tie-1	Tie1	40	323.31	557	3.41	3.10	8.55
Metastasis suppressor protein 1	Mtss1	8	16.08	28	1.43	3.08	8.43
Abl interactor 1	Abi1	15	40.08	79	1.35	3.05	8.27
Mesoderm-specific transcript protein	Mest	4	19.70	8	1.46	2.91	7.51
Lipid phosphate phosphohydrolase 3	Ppap2b	6	13.16	49	2.68	2.87	7.31
Vascular endothelial growth factor receptor 3	Flt4	30	127.44	195	1.85	2.80	6.98
	Flrt2	14	32.61	64	1.51	2.73	6.65
Tumor susceptibility gene 101 protein	Tsg101	16	87.37	81	3.00	2.59	6.03
Activated CDC42 kinase 1	Tnk2	6	9.25	12	1.62	2.55	5.86
Vacuolar protein sorting-associated protein 28 homolog	Vps28	10	41.14	53	2.52	2.51	5.68
Interferon-induced transmembrane protein 2	Ifitm2	3	23.99	22	2.95	2.43	5.37
Multivesicular body subunit 12B	Mvb12b	8	19.59	24	1.53	2.42	5.35
General receptor for phosphoinositides 1-associated scaffold protein	Grasp	13	48.40	100	1.71	2.23	4.71
Anthrax toxin receptor 2	Antxr2	7	15.38	22	1.47	2.12	4.36
ABI gene family member 3	Abi3	6	11.29	16	1.54	2.12	4.35
Caskin-2	Caskin2	53	323.31	1066	1.85	2.10	4.29
Mitogen-activated protein kinase 14	Mapk14	9	36.65	55	2.23	2.07	4.21
SH2 domain-containing adapter protein E	She	7	26.80	59	1.60	2.07	4.19
Nck-associated protein 1	Nckap1	50	323.31	410	1.61	1.93	3.80
Growth arrest-specific protein 7	Gas7	6	8.81	11	1.62	1.85	3.61
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	Arap3	27	66.58	148	1.95	1.84	3.58
Cytoplasmic FMR1-interacting protein 1	Cyfip1	55	323.31	351	1.48	1.82	3.53
Homer protein homolog 3	Homer3	17	195.55	225	2.89	1.81	3.50
Wiskott-Aldrich syndrome protein family member 2	Wasf2	14	99.56	123	2.39	1.77	3.42
Tyrosine-protein kinase Yes	Yes1	18	79.11	132	1.31	1.60	3.03
NCK-interacting protein with SH3 domain	Nckipsd	11	19.20	27	1.60	1.59	3.02
	Slc25a1	10	23.81	53	1.38	1.55	2.92
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	Inpp5d	41	166.04	266	3.00	1.52	2.86
KN motif and ankyrin repeat domain-containing protein 2	Kank2	9	26.94	44	1.43	1.45	2.74
60S ribosomal protein L9	Rpl9	7	20.51	34	1.57	1.42	2.67
Brain-specific angiogenesis inhibitor 1-associated protein 2	Baiap2	8	13.92	18	1.47	1.35	2.55
Ephrin-B1	Efnb1	4	6.03	8	1.45	1.33	2.52
Lipoma-preferred partner homolog	Lpp	13	66.64	77	1.47	1.33	2.51
Programmed cell death protein 6	Pdcd6	6	35.84	46	1.75	1.30	2.46
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	Ndufs4	4	12.28	23	1.45	1.25	2.38
Monoacylglycerol lipase ABHD6	Abhd6	2	6.90	2	1.53	1.22	2.33
	Gm8730	10	13.33	12	1.84	1.16	2.23
Coiled-coil domain-containing protein 124	Ccdc124	5	5.84	10	1.96	1.11	2.16
Protein phosphatase 1 regulatory subunit 21	Ppp1r21	13	27.59	23	1.72	1.08	2.12
Transmembrane protein 33	Tmem33	5	24.17	42	1.33	1.08	2.12
Platelet endothelial cell adhesion molecule	Pecam1	25	228.69	366	2.12	1.04	2.06
40S ribosomal protein S16	Rps16	8	27.46	68	2.03	1.01	2.01