Fig. 2.

Tissue-specific functional analysis of aging in WT Drosophila. A, Clustering of proteins using the fuzzy c-means method according to their abundance changes during the aging process. The proteins localized in the middle cluster were generally stable. In contrast, the proteins in cluster 1 and cluster 5 changed dramatically with age, whereas proteins in cluster 2 and cluster 4 changed mildly. B, Pathway analysis for proteins in different clusters. Many tissue-specific and common pathways were identified for proteins in different clusters.