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. 2019 Jul 23;18(10):2003–2017. doi: 10.1074/mcp.RA118.001298

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© 2019 Zhang et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 4. — KEGG pathway analyses of the quantitative succinylome highlights the regulation of ScCobB2 in protein biosynthesis and carbon metabolism. The up-regulated succinylation proteins were enriched in protein biosynthesis and carbon metabolism pathways by KEGG pathway analyses (A). The hypersuccinylated proteins enriched in ribosome (B), pyruvate metabolism (C), TCA cycle (D), and glycolysis/gluconeogenesis (E) were mapped onto KEGG pathways and shown as in middle panels. The succinylated proteins identified in this study are highlighted in brown while the up-regulated succinylation proteins are highlighted in magenta. Typical MS/MS spectra of K^Suc peptides from the enzymes in protein biosynthesis and carbon metabolism pathways were shown as in (F). Glk: glucokinase; Pgi: glucose-6-phosphate isomerase; PfkA: 6-phosphofructokinase; Fba: fructose-bisphosphate aldolase; GapA: glyceraldehyde-3-phosphate dehydrogenase; Pgk: phosphoglycerate kinase; GpmA: phosphoglycerate mutase; Eno: phosphopyruvate hydratase; Pyk: pyruvate kinase; AceE: pyruvate dehydrogenase E1 component; AceF: pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); Lpd: dihydrolipoamide dehydrogenase; Adh: alcohol dehydrogenase; Aldh: aldehyde dehydrogenase; AcsA: acetyl-CoA synthetase; CS: citrate synthase; ACO: aconitate hydratase; IDH: isocitrate dehydrogenase; SucA: 2-oxoglutarate dehydrogenase E1 component; SucB: 2-oxoglutarate dehydrogenase E2 component; SucC: succinyl-CoA synthetase subunit beta; SucD: succinyl-CoA synthetase subunit alpha; FH: fumarate hydratase; MDH: malate dehydrogenase; Tuf1: elongation factor Tu-1.