Table 1.
Baseline characteristics of high‐risk individuals who had surgery after detection of a suspicious pancreatic lesion or were diagnosed with advanced pancreatic cancer
| High‐risk individuals who had surgery (n = 71) | High‐risk individuals diagnosed with advanced PDAC (n = 5) | |
|---|---|---|
| Age at surgery or diagnosis (years) * | 60·3(11·6) (59·8; 36–80) | 70·5(6·6) (65–80) |
| Sex ratio (M : F) | 37 : 34 | 1 : 4 |
| Ethnicity | ||
| White | 67 (94) | 5 (100) |
| Black | 3 (4) | ‐ |
| Other | 1 (1) | – |
| Genetic background | ||
| Familial pancreatic cancer | 52 (73) | 4 (80) |
| CDKN2A (FAMMM syndrome) | 7 (10) | – |
| BRCA2 (HBOC) | 3 (4) | – |
| Peutz–Jeghers syndrome | 3 (4) | 1 (20) |
| BRCA1 (HBOC) | 1 (1) | – |
| TP53 (Li–Fraumeni syndrome) | 1 (1) | – |
| MMR (Lynch syndrome) | 1 (1) | – |
| APC | 1 (1) | – |
| ATM | 1 (1) | – |
| PRRS1 (hereditary pancreatitis) | 1 (1) | – |
| No. of first‐degree relatives with PDAC * | 1·5(0·8) (1·0; 0–3) | 1·4(0·9) (0–2) |
| No. of second‐degree relatives with PDAC * | 1·1(1·0) (1·0; 0–4) | 0·3(0·6) (0–1) |
| Youngest family member affected by PDAC * | 55·5(10·8) (33–77) | 63·3(7·5) (52–68) |
| BMI (kg/m 2 ) * | 27·3(5·1) (26·6; 18–48) | 26·1(3·7) (23–31) |
| Personal history of diabetes | 11 (15) | 2 (40) |
| Duration of diabetes before surgery or diagnosis (months) * | 36·6(23·7) (45·0; 0–63) | 66·0(76·4) (12–120) |
| Personal history of pancreatitis | 9 (13) | 1 (20) |
| Smoking behaviour | ||
| Never smoker | 46 (65) | 3 (60) |
| Former smoker | 20 (28) | 2 (40) |
| Current smoker | 3 (4) | – |
| No data | 2 (3) | |
| ≥ 10 pack‐years in total | 11 (15) | 1 (20) |
| ≥ 20 pack‐years in total | 4 (6) | – |
| Alcohol consumption | ||
| Never consumer | 38 (54) | 2 (40) |
| Former consumer | 12 (17) | 1 (20) |
| Current consumer | 19 (27) | 2 (40) |
| No data | 2 (3) | – |
| ≥ 10 units per week (current or past) | 5 (7) | – |
| ≥ 20 units per week (current or past) | 2 (3) | – |
Values in parentheses are percentages unless indicated otherwise;
*
values are mean(s.d.) (median; range). PDAC, pancreatic ductal adenocarcinoma; FAMMM, familial atypical multiple mole melanoma syndrome; HBOC, hereditary breast and ovarian cancer; MMR, mismatch repair genes; APC, adenomatous polyposis coli; ATM, ataxia telangiectasia mutated.