Table 4.
Univariable and multivariable analysis of factors possibly associated with high‐risk neoplastic precursor lesions or pancreatic ductal adenocarcinoma in the resection specimen
| Univariable analyses | Multivariable analyses | |||
|---|---|---|---|---|
| Unadjusted OR | P | Adjusted OR | P | |
| Age ≥ 65 years at surgery | 4·11 (1·44, 11·70) | 0·007 | 7·53 (1·6, 35·0) | 0·010 |
| Female sex | 3·82 (1·42, 10·25) | 0·007 | 5·78 (1·4, 24·3) | 0·017 |
| White ethnicity | 0·25 (0·03, 2·57) | 0·321 | ||
| Carrier of a gene mutation | 2·40 (0·80, 7·16) | 0·113 | 4·92 (1·1, 22·6) | 0·040 |
| ≥ 2 first‐degree relatives affected by PDAC | 2·40 (0·91, 6·36) | 0·076 | 1·71 (0·4, 7·2) | 0·462 |
| Family member aged < 50 years affected by PDAC | 1·15 (0·34, 3·85) | 0·820 | ||
| BMI ≥ 25 kg/m2 | 0·57 (0·20, 1·67) | 0·303 | ||
| Personal history of diabetes | 1·83 (0·49, 6·77) | 0·505 | ||
| Personal history of pancreatitis | 0·69 (0·16, 3·03) | 0·727 | ||
| Current or former smoker | 1·00 (0·36, 2·75) | 1·000 | ||
| > 10 pack‐years of smoking | 0·95 (0·14, 6·28) | 1·000 | ||
| Current or former consumption of alcohol | 0·70 (0·27, 1·84) | 0·470 | ||
| Detection of lesion at follow‐up visit | 1·14 (0·45, 2·92) | 0·782 | ||
| Solid lesion type (versus cystic lesion) | 1·11 (0·40, 3·07) | 0·839 | ||
| Location of lesion in head/uncinate region (versus location in body/tail) | 2·33 (0·83, 6·56) | 0·105 | 4·23 (1·1, 16·9) | 0·041 |
| Lesion size ≥ 1 cm | 1·26 (0·39, 4·12) | 0·702 | ||
| Surgery after 2011 | 1·47 (0·54, 4·01) | 0·448 | ||
Values in parentheses are 95 per cent confidence intervals. OR, odds ratio; PDAC, pancreatic ductal adenocarcinoma.