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. 2019 Oct 1;9:14075. doi: 10.1038/s41598-019-50267-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Conventional tetraspanin topology. Depicted is the typical topology of a tetraspanin. Intracellular domains include the N-terminus, the small intracellular loop (SIL), and the C-terminus, which are all short (for exceptions see Table S1). At the extracellular site, a small extracellular loop (SEL) connects transmembrane segment 1 (TMS1) and TMS2 and a large extracellular loop (LEL) TMS3 and TMS4. For the complete tetraspanin and its different segments, the three numbers (xx-yy-zz) indicate the sequence lengths of the shortest sequence (xx), the average sequence (yy) and the longest sequence (zz) (for details see Table S1).