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. 2019 Oct 1;9:14075. doi: 10.1038/s41598-019-50267-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Classes of tetraspanins. Based on the analysis illustrated for the examples Tspan6, CD81 and CD82 (Fig. 3), all tetraspanins and their isoforms were classified as mono-, di-, tri- or tetraspanins. Subclasses result from the type of remaining TMSs, or whether a novel TMS is formed. Alteration of the N- or C- terminus, or the LEL define further subclasses. Isoforms with a partially or completely inverted topology are marked by an asterisk.