Table 1.
Tetraspanin splice variants.
| Historic Name | Systematic Name | mRNA (NM_) | Protein (NP_) | Isoform | 5′UTR | ORF Exons | 3′UTR | uORF | Alternative stop codon | Frame shift |
|---|---|---|---|---|---|---|---|---|---|---|
| Tspan1 | 005727.4 | 005718.2 | 1 | 1–3 | 3–9 | 9 | X | |||
| Tspan2 | 005725.6 | 005716.2 | 1 | 1 | 1–8 | 8 | ||||
| 001308315.1 | 001295244.1 | 2 | Δ4 | |||||||
| 001308316.1 | 001295245.1 | 3 | Δ7 | |||||||
| Tspan3 | 005724.6 | 005715.1 | 1 | 1 | 1–7 | 7 | ||||
| 198902.3 | 944492.1 | 2 | Δ3 | |||||||
| 001168412.2 | 001161884.1 | 3 | Δ2 | |||||||
| Tspan4 | 001025237.1 | 001020408.1 | 1 | 1–3 | 3–9 | 9 | X | |||
| 001025234.1 | 001020405.1 | 1 | ↔1 | |||||||
| 001025235.1 | 001020406.1 | 1 | ↔1 | |||||||
| 001025236.1 | 001020407.1 | 1 | ↔1 | |||||||
| 003271.5 | 003262.1 | 1 | ↔1 | |||||||
| 001025238.2 | 001020409.1 | 1 | ↔1, Δ2 | |||||||
| 001025239.1 | 001020410.1 | 2 | Δ1, Δ3 | Δ3 | ||||||
| Tspan5 | 005723.4 | 005714.2 | 1 | 1 | 1–8 | 8 | ||||
| Tspan6 | 003270.4 | 003261.1 | 1 | 1 | 1–7 | 7–8 | ||||
| 001278740.2 | 001265669.1 | 2 | 1ASS | 1ASS | X | |||||
| 001278741.1 | 001265670.1 | 2 | 1ASS | 1ASS | X | |||||
| 001278742.1 | 001265671.1 | 3 | 1ASS | 1ASS, Δ7 | Δ7 | X | Δ7 | |||
| 001278743.1 | 001265672.1 | 4 | 1ASS | 1ASS, Δ6 | X | |||||
| Tspan7 | 004615.3 | 004606.2 | 1 | 1 | 1–7 | 7–8 | ||||
| Tspan8 | 004616.3 | 004607.1 | 1 | 1–2 | 2–9 | 9 | ||||
| 001369760.1 | 001356689.1 | 1 | Δ1, 2ASS | |||||||
| Tspan9 | 006675.5 | 006666.1 | 1 | 1–3 | 3–9 | 9 | ||||
| 001168320.1 | 001161792.1 | 1 | Δ2 | |||||||
| Tspan10 | 001290212.1 | 001277141.1 | 1 | 1 | 1–4 | 4 | ||||
| 031945.4 | 114151.3 | 2 | Δ1 | Δ1 | ||||||
| Tspan11 | 001080509.2 | 001073978.1 | 1 | 1–2 | 2–8 | 8 | X | |||
| 001370301.1 | 001357230.1 | 2 | Δ2 | Δ2 | ||||||
| 001370302.1 | 001357231.1 | 1 | ↔1 | |||||||
| Tspan12 | 012338.4 | 036470.1 | 1 | 1–2 | 2–8 | 8 | ||||
| Tspan13 | 014399.4 | 055214.1 | 1 | 1 | 1–6 | 6 | ||||
| Tspan14 | 030927.3 | 112189.2 | 1 | 1–2 | 2–9 | 9 | ||||
| 001128309.2 | 001121781.1 | 2 | Δ3–5 | |||||||
| 001351266.1 | 001338195.1 | 1 | +1 | |||||||
| 001351267.3 | 001338196.1 | 1 | +1 | |||||||
| 001351268.1 | 001338197.1 | 1 | +1 | |||||||
| 001351269.1 | 001338198.1 | 1 | ↔1 | |||||||
| 001351270.1 | 001338199.1 | 1 | ↔1 | X | ||||||
| 001351271.1 | 001338200.1 | 1 | ↔1 | |||||||
| 001351272.1 | 001338201.1 | 1 | ↔1 | |||||||
| Tspan15 | 012339.5 | 036471.1 | 1 | 1 | 1–8 | 8 | ||||
| 001351263.1 | 001338192.1 | 2 | Δ2–3 | |||||||
| Tspan16 | 001282509.2 | 001269438.1 | 1 | 1 | 1–7 | 7 | ||||
| 012466.4 | 036598.1 | 2 | ↔7 | ↔7 | ↔7 | |||||
| 001282510.2 | 001269439.1 | 3 | Δ3 | |||||||
| Tspan17 | 012171.3 | 036303.1 | 1 | 1 | 1–9 | 9 | ||||
| 130465.5 | 569732.2 | 2 | 6ASS | |||||||
| 001006616.3 | 001006617.2 | 3 | 6ASS, 8ASS | 8ASS | 8ASS | |||||
| 001366491.2 | 001353420.1 | 4 | 1ASS | 6ASS, 7ASS | ||||||
| 001366492.2 | 001353421.1 | 5 | 1ASS | Δ2–3, 6ASS | ||||||
| Tspan18 | 130783.5 | 570139.3 | 1 | 1–3 | 3–9 | 9 | ||||
| Tspan19 | 001100917.2 | 001094387.1 | 1 | 1–2 | 2–9 | 9 | ||||
| UPK1b | Tspan20 | 006952.4 | 008883.2 | 1 | 1–2 | 2–8 | 8 | |||
| UPK1a | Tspan21 | 007000.3 | 008931.1 | 1 | 1–2 | 2–9 | 9 | |||
| 001281443.1 | 001268372.1 | 2 | +6 | +6 | +6 | |||||
| PRPH2 | Tspan22 | 000322.5 | 000313.2 | 1 | 1 | 1–3 | 3 | |||
| ROM1 | Tspan23 | 000327.3 | 000318.1 | 1 | 1 | 1–3 | 3 | |||
| CD151 | Tspan24 | 004357.5 | 004348.2 | 1 | 1–3 | 3–9 | 9 | |||
| 139030.3 | 620599.1 | 1 | Δ2 | |||||||
| 139029.1 | 620598.1 | 1 | 1ASS | |||||||
| 001039490.1 | 001034579.1 | 1 | 1ASS Δ2 | |||||||
| CD53 | Tspan25 | 001040033.1 | 001035122.1 | 1 | 1–3 | 3–9 | 9 | |||
| 000560.4 | 000551.1 | 1 | Δ1, 2ASS | |||||||
| 001320638.1 | 001307567.1 | 2 | Δ1, 2ASS | Δ6–7 | ||||||
| from Natural Killer Cells cDNA | 3 | N/A | Δ5–8 | N/A | N/A | |||||
| CD37 | Tspan26 | 001774.3 | 001765.1 | 1 | 1 | 1–8 | 8 | |||
| 001040031.2 | 001035120.1 | 2 | 1ASS | |||||||
| CD82 | Tspan27 | 002231.4 | 002222.1 | 1 | 1–3 | 3–10 | 10 | |||
| 001024844.1 | 001020015.1 | 2 | Δ6 | |||||||
| from Human Brain cDNA | 3 | N/A | Δ9 | N/A | N/A | |||||
| Lee et al. 2003 | 4 | N/A | Δ7 | N/A | N/A | |||||
| CD81 | Tspan28 | 004356.3 | 004347.1 | 1 | 1 | 1–8 | 8 | |||
| 001297649.1 | 001284578.1 | 2 | Δ1 | Δ1, 2ASS | ||||||
| CD9 | Tspan29 | 001769.4 | 001760.1 | 1 | 1 | 1–8 | 8 | |||
| 001330312.2 | 001317241.1 | 2 | ↔1 | ↔1 | X | |||||
| CD63 | Tspan30 | 001780.5 | 001771.1 | 1 | 1–2 | 2–8 | 8 | |||
| 001257389.1 | 001244318.1 | 1 | ↔1 | X | ||||||
| 001257390.1 | 001244319.1 | 1 | ↔1 | |||||||
| 001257391.1 | 001244320.1 | 1 | Δ1 | 2ASS | ||||||
| 001257392.1 | 001244321.1 | 2 | Δ1 | 3ASS | ||||||
| 001257400.1 | 001244329.1 | 3 | ↔1, Δ2 | Δ2 | ||||||
| 001257401.1 | 001244330.1 | 3 | ↔1, Δ2 | Δ2 | ||||||
| 001267698.1 | 001254627.1 | 1 | 1ASS | |||||||
| Tspan31 | 005981.5 | 005972.1 | 1 | 1 | 1–6 | 6 | ||||
| 001330168.2 | 001317097.1 | 2 | Δ2–3 | |||||||
| 001330169.2 | 001317098.1 | 3 | 1ASS | |||||||
| Tspan32 | 139022.2 | 620591.3 | 1 | 1 | 1–10 | 10 | ||||
| Tspan33 | 178562.5 | 848657.1 | 1 | 1 | 1–8 | 8 | X | |||
Left, historic names used with priority over the systematic names in the NCBI database. More historic names with lower priority are listed in Table S1. Second and third columns, mRNA variants are sorted by systematic name, next sorted by the NCBI variant number for the mRNA. For Tpan16 and Tspan21, the first mRNAs variants are trispanins, and the second ones are tetraspanins. In these cases, we moved up the second mRNA variants referring to them as conventional tetraspanins (isoforms 1). Forth column, NCBI reference sequence number for protein (NP). Column 5 lists the isoform number. Column 6 lists the exons forming the 5′ UTR of the respective splice variant 1, being the reference sequence for comparisons with the 5′ UTR of the other alternatively spliced variants. For the alternatively spliced variants, the column lists the eliminated exon(s) (∆), the number of an exchanged exon (↔) or the number of an exon after which another exon has been introduced (+). In case an alternative splice site (ASS) is used, the number of the exon with the ASS is given. Columns 7 and 8 provide the same information for the ORF and the 3′ UTR, respectively. Column9; a cross indicates an open reading frame upstream of the ORF. Modifications by AS generating a new stop codon are shown in column 10, and modifications generating a frame shift in column 11. N/A, not available.