Table 1.
Hematologic data and liver function test of Swiss mice immunized with nano-iCnB.
| Parameters | Nano-milliQW | Non-immunized-control | Nano-iCnB | Non-immunized-challenged | Reference |
|---|---|---|---|---|---|
| Total Leukocytes, (mm3) | 9600 (864)ns | 8466 (982) | 11733 (499) | 12933 (7128) | 4300–10000, (mm3) |
| Hemoglobin, (g/dL) | 14,73 (0,51)ns | 10,60 (2,80) | 16,17 (0,51) | 20,73 (1,80)* | 13–17, (g/dL) |
| Hematocrit, (%) | 44,33 (1,53)ns | 38,80 (4,50) | 48,67 (1,53) | 64,67 (3,05)* | 39–51, (%) |
| Alanine Transaminase (ALT), (U/L) | 38 (12)ns | 32 (12) | 31 (11) | 211 (73)* | 26–60, (U/L) |
| Aspartate aminotransferase (AST), (U/L) | 130 (65)ns | 156 (38) | 180 (49) | 414 (72)* | 81–184, (U/L) |
| Alkaline phosphatase (AP), (U/L) | 125 (74)ns | 183 (7,20) | 190 (6) | 206 (28) | 63–196, (U/L) |
Non-immunized-control (healthy animals); nano-milliQW; nano-iCnB; Non-Immunized-challenged with 157 LD50.g−1. ns – not significant - sera from Swiss mice non-immunized-control vs sera from Swiss mice inoculated with nano-milliQW. *significant - hemoglobin (p < 0.05); hematocrit (p < 0.05); ALT (p < 0.04); AST (p < 0.01) sera from immunized Swiss mice vs Non-immunized-challenged.