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. 2019 Sep 25;10:1212. doi: 10.3389/fphys.2019.01212

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Copyright © 2019 Martinez-Mateu, Saiz and Aromolaran.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the effects of HFD and rapid pacing on atrial electrical properties in guinea pig heart. Short-term high-fat diet induced significant electrical remodeling of I_K and I_Ca,L while I_Kur and I_K1 remained unchanged compared to LFD controls. When HFD is combined with pacing I_Kur is significantly reduced while I_K1 is increased in line with their roles in pathogenesis of supraventricular arrhythmias such as atrial fibrillation. The size of red arrows indicates change in the current densities of the ion channels.