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. 2019 Sep 25;13:1022. doi: 10.3389/fnins.2019.01022

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Copyright © 2019 Kadoya and Sasai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A regulatory loop composed of Shh, FoxA2, and RNF152 modulates FP cell proliferation. FoxA2 expression is induced by Shh, whereas RNF152 is a target gene of FoxA2. RNF152 blocks the cell proliferation through by negatively regulating mTOR signaling. Transcriptional regulation is indicated by solid arrows; activation, and inactivation with protein interactions or modifications are indicated by dotted arrows; the regulation of cell proliferation by the activation of p70S6K is apparently indirect, which is indicated by the gray arrow.