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Ongoing clinical trials involving direct targeting of KRAS.
| Compounds | Company | Mechanism | Clinical trial |
|---|---|---|---|
| AMG 510 | Amgen/Carmot Therapeutics | KRASG12C inhibitor | NCT03600883 |
| MRTX849 | Mirati (ex Array) | KRASG12C inhibitor | NCT03785249 |
| KRAS TCR | Gilead (ex Kite/NCI) | Anti-KRASG12D engineered T-cell receptor | NCT03745326 |
| AZD4785 | AstraZeneca/Ionis | KRAS antisense oligonucleotide | NCT03101839 |
