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. 2019 Sep 25;10:2232. doi: 10.3389/fmicb.2019.02232

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Copyright © 2019 Rodrigo-Torres, Yépez, Aznar and Arahal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genetic context of aadA2 gene (streptomycin 3″-O-adenylyltransferase (EC 2.7.7.47) @ Spectinomycin 9-O-adenylyltransferase) in L. plantarum CECT 8965 (L. plantarum M9, first line in the image). The aadA2 gene (red arrow, immediately below the line) is located alone with a hypothetical protein (gray arrow, over the line) in the holder contig. Closely related genes and their context are shown below: S. enterica sub = Salmonella enterica subsp. enterica serovar Choleraesuis strain SC-B67, C. cellylolytic = Clostridium cellulolyticum H10. Description of genes in the closest strain of Salmonella enterica subsp. enterica serovar Choleraesuis strain SC-B67, from left to right: resolvase, unknown function, 2: mobile element protein, transposon Tn21 modulator protein, 10: integron integrase Intl1, hydrolase, alpha/beta fold family, Phosphoserine phosphatase (EC 3.1.3.3), 1: streptomycin 3″-O-adenylyltransferase (EC 2.7.7.47), florfenicol/chloramphenicol transporter FloR, 1: streptomycin 3″-O-adenylyltransferase (EC 2.7.7.47) @ Spectinomycin 9-O-adenylyltransferase, 4: ethidium bromide-methyl viologen resistance protein EmrE, transposase, 7: dihydropteroate synthase (EC 2.5.1.15), unknown protein, dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases), macrolide-efflux protein, 2: mobile element protein, unknown function, unknown function, ADP-heptose:LPS heptosyltransferase.