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. 2019 Sep 25;10:1064. doi: 10.3389/fphar.2019.01064

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Copyright © 2019 Moles, Kavallaris and Fernàndez-Busquets

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Estimation of antimalarial P^H+ coefficient values for PC-based LPs. (A) P^H+-dependent drug EEt vs. EEe variances for all experimental pH values studied in accordance with the D _P,PH+ distribution model. (B) Isolation of P^H+ coefficient exhibiting least cumulative variances. Normalized variances are individually illustrated for each drug and pH value using the Hue color function (light blue and dark red as maximum and minimum variance levels, respectively).