Table 1.

Experimental vs. theoretical EEs for PC-LP suspensions as a function of pH and D_P, D_P,PH+, D_P,PH+,P2H+ drug distribution models.

Drug	pH	%EEe	%EEt (D P)	ΔEE (%)/p value	%EEt (D P,PH+)	ΔEE (%)/p value	%EEt (D P,PH+,P2H+)	ΔEE (%)/p value
Quinine	4.0	38.2 ± 6.6	2.4	−93.7/<10−5	37.1	−2.9/0.87	–	–
	6.0	45.7 ± 7.0	2.9	−93.7/<10−5	54.0	+18.2/0.23	–	–
	7.4	62.0 ± 2.7	13.6	−78.1/<10−5	56.3	−9.2/0.03	–	–
	9.0	71.2 ± 5.2	74.3	+4.4/0.55	77.8	+9.3/0.21	–	–
$\Sigma |∆\mathrm{EE}|/\widetilde{∆\mathit{EE}}$			–	269.9/85.9	–	39.6/9.3	–
Primaquine	4.0	9.5 ± 2.0	2.4	−74.7/4.0×10−4	39.6	+316.8/<1×10−5	–	–
	6.0	60.5 ± 7.6	2.5	−95.9/<10−5	43.0	−28.9/0.02	–	–
	7.4	52.0 ± 5.3	3.8	−92.7/<10−5	43.5	−16.3/0.11	–	–
	9.0	55.4 ± 5.9	36.8	−33.6/1.5×10−3	56.2	+1.4/0.89	–	–
$\Sigma |∆\mathrm{EE}|/\widetilde{∆\mathit{EE}}$			–	296.9/83.7	–	363.4/22.6	–
Tafenoquine	4.0	54.0 ± 8.1	2.5	−95.4/<10−5	61.5	+13.9/0.35	–	–
	6.0	71.6 ± 14.8	7.3	−89.8/1.4×10−5	65.6	−8.4/0.69	–	–
	7.4	73.9 ± 8.0	58.0	−21.5/0.04	76.3	+3.2/0.76	–	–
	9.0	86.1 ± 8.9	98.1	+13.9/0.18	98.1	+13.9/0.18	–	–
$\Sigma |∆\mathrm{EE}|/\widetilde{∆\mathit{EE}}$			–	220.6/55.7	–	39.4/11.2	–
Quinacrine	4.0	11.3 ± 2.1	2.4	−78.8/1.7×10−5	2.5	−77.9/2.1×10−5	14.6	+29.2/0.12
	6.0	22.5 ± 6.9	2.4	−89.3/3.9×10−3	8.0	−64.4/0.04	18.8	−16.4/0.60
	7.4	63.5 ± 3.5	14.7	−76.9/<10−5	61.3	−3.5/0.52	63.1	−0.6/0.90
	9.0	94.8 ± 2.7	97.9	+3.3/0.25	98.3	−3.7/0.20	98.3	+3.7/0.20
$\Sigma |∆\mathrm{EE}|/\widetilde{∆\mathit{EE}}$			–	248.3/77.9	–	149.5/34.1	–	49.9/10.1
Chloroquine	4.0	9.2 ± 2.3	2.4	−73.9/2.9×10−3	2.4	−73.9/2.9×10−3	14.6	+58.7/0.02
	6.0	23.7 ± 4.6	2.4	−89.9/<10−5	5.1	−78.5/6.3×10−5	16.6	−30.0/0.13
	7.4	45.1 ± 8.3	8.6	−80.9/1.1×10−5	43.1	−4.4/0.81	47.1	+4.4/0.80
	9.0	76.1 ± 10.0	95.9	+26.0/0.04	96.6	+26.9/0.04	96.6	+26.9/0.04
$\Sigma |∆\mathrm{EE}|/\widetilde{∆\mathit{EE}}$			–	270.7/77.4	–	183.7/50.4	–	120/28.5

Variations in EE (ΔEE, %) and Z-test p values were obtained when comparing experimental (reference condition) vs. theoretical EE values.