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. 2019 Sep 25;10:1225. doi: 10.3389/fphys.2019.01225

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Copyright © 2019 Zhou, Zhang, Zhang, Yu, Sun, Zhu, Li, Liang, Han and Qin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PINK1 deficiency prevented cisplatin-induced mitophagy. (A) Representative images of LC3B immunostaining. (B) Representative transmission electron microscope images of renal proximal tubular cells and mitochondria. L indicated the proximal tubular lumen. The arrow indicated a representative mitophagosome. (C) Quantitative analysis of the length/width of mitochondria in proximal tubular cells. (D) Transmission electron microscope images of large vacuoles containing numerous autophagosomes and mitophagosomes in cisplatin treated WT rats. (E) Quantitative analysis of the western blotting of LC3BII. (F) Representative western blot bands of LC3BII in renal cortex. N = 3 in WT + saline group and KO + saline group, N = 4 in WT + cisplatin group and KO + cisplatin group. ^∗P < 0.05, WT + cisplatin vs. WT + saline; ^#P < 0.05, KO + cisplatin vs. WT + cisplatin; ^ΔP < 0.05, KO + cisplatin vs. KO + saline. Data are mean ± SE.