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. 2019 Sep 25;10:1225. doi: 10.3389/fphys.2019.01225

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Copyright © 2019 Zhou, Zhang, Zhang, Yu, Sun, Zhu, Li, Liang, Han and Qin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Altered expression of PINK1, Parkin and BNIP3L during cisplatin treatment in PINK1 WT and KO rats. (A) Real-time quantitative PCR analysis of Pink1 mRNA expression in renal cortex. (B) Real-time quantitative PCR analysis of Parkin mRNA expression in renal cortex. (C) Quantitative analysis of the western blotting of Parkin. (D) Quantitative analysis of the western blotting of BNIP3L. (E) Representative western blot bands of Parkin and BNIP3L in renal cortex. N = 3 in WT + saline group and KO + saline group, N = 4 in WT + cisplatin group and KO + cisplatin group. ^∗P < 0.05, WT + cisplatin vs. WT + saline; ^#P < 0.05, KO + cisplatin vs. WT + cisplatin; ^ΔP < 0.05, KO + cisplatin vs. KO + saline; ^$P < 0.05, KO + saline vs. WT + saline. Data are mean ± SE.