Table 4.
Donor hematopoietic chimerism at baseline and after 2 years of IV-ERT augmentation using a generalized estimated equations model to assess intra-patient changes.
| Condition | n | Baseline GM (95% CI) | Month 24 GM (95% CI) | GM Ratio (95% CI) | p-value (ratio) |
|---|---|---|---|---|---|
| All | 10 | 89 (83, 96) | 86 (76, 97) | 0.97 (0.91, 1.03) | 0.28 |
| Low/No ADA | 7 | 90 (83, 98) | 86 (74, 101) | 0.96 (0.87, 1.05) | 0.32 |
| High ADA | 3 | 87 (74, 101) | 86 (71, 103) | 0.99 (0.95, 1.03) | 0.54 |
GM = geometric means from the generalized estimated equations model; GM ratio = ratio of geometric means at 24 months compared to baseline; CI = confidence interval; ADA = anti-laronidase drug antibody; p-values are from tests of the null hypothesis that the true GM ratio (month 24/baseline) is 1.