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. 2019 Oct 1;9:14118. doi: 10.1038/s41598-019-50729-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SIM in phases of chronic HBV. (A) Significance evaluation of different virological, biochemical and immunological markers between phases of chronic HBV infection. The broken line indicates the significance threshold. Nonsignificant differences are marked with black dots. Significant differences are marked with a colored dot. Colored dots according to group color connotes significantly higher values of the parameter in this group compared to the other group. (B) Heat map showing the expression pattern of 14 soluble immune markers normalized by setting mean = 1 and variance = 0. The elements are colored according to the value of each SIM for each phase.